AICAR

AICAR Peptide

AICAR is an analog of adenosine monophosphate (AMP), a nucleotide that is considered to play an important role in cellular energy metabolism. It has been studied for its potential applications in research, particularly in reducing reperfusion injury after tissue ischemia and mitigating metabolic disorders. AICAR has been suggested to exert this potential by apparently activating AMP-activated protein kinase (AMPK), an enzyme that regulates various metabolic processes. AMPK potentially plays a role in restoring energy balance. It might do this by inhibiting anabolic processes: energy-consuming pathways like protein and fatty acid synthesis. Simultaneously, it might activate catabolic processes, such as the breakdown of glucose and fats, which generate ATP, thereby increasing the energy supply. There is also a possibility that AMPK influences various other cellular processes, including autophagy (the process by which cells clean out damaged components), mitochondrial biogenesis (the creation of new mitochondria), and the regulation of inflammation and stress responses. This broad range of actions suggests that AMPK might be involved in regulating several aspects of cellular and organismal function.

By potentially activating AMPK, AICAR is posited to possibly increase glucose uptake in skeletal muscle, enhance insulin sensitivity, and improve glucose tolerance. AICAR has also been suggested by researchers to have anti-inflammatory potential and may improve physical performance in certain experimental models.

Chemical Makeup

Molecular formula : C 9 H 15 N 4 O 8 P Molecular Weight: 338.21 g/mol Other known titles: AICA ribonucleotide

Research and Clinical Studies

AICAR Peptide and Tissue Protection

AICAR may have organ-protective potential, especially against ischemia and reperfusion injury. The nucleotide has been suggested to potentially reduce myocardial infarction size and improve cardiac function in an animal model of myocardi